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Tipo: conferenceObject
Título: Neutron cross-sections database for amino acids and proteins analysis
Autor(es): Voi, Dante Luiz
Ferreira, Francisco
Nunes, Rogerio Chaffin
Resumo: Biological materials may be studied using neutrons as an unconventional tool of analysis. Dynamics and structures data can be obtained for amino acids, protein and others cellular components by neutron crosssections determinations especially for applications in nuclear purity and conformation analysis. The instrument used for this is the crystal spectrometer of the Instituto de Engenharia Nuclear (IEN-CNEN-RJ), the only one in Latin America that uses neutrons for this type of analyzes and it is installed in one of the reactor Argonauta irradiation channels. The experimentally values obtained are compared with calculated values using literature data with a rigorous analysis of the chemical composition, conformation and molecular structure analysis of the materials. A neutron cross-section database was constructed to assist in determining molecular dynamic, structure and formulae of biological materials. The database contains neutron cross-sections values of all amino acids, chemical elements, molecular groups, auxiliary radicals, as well as values of constants and parameters necessary for the analysis. An unprecedented analitycal procedure was developed using the neutron crosssection parceling and grouping method for data manipulation. This database is a result of easurements obtained from twenty amino acids that were provided by different manufactories and are used in oral administration in hospital individuals for nutritional applications. It was also constructed a small data file of compounds with different molecular groups including carbon, nitrogen, sulfur and oxygen, all linked to hydrogen atoms. A review of global and national scene in the acquisition of neutron cross sections data, the formation of libraries and the application of neutrons for analyzing biological materials is presented. This database has further application in protein analysis and the neutron cross-section from the insulin was stimated.
Palavras-chave: INAC 2015
Biological materials
Proteins analysis
Idioma: eng
País: Brasil
Editor: Instituto de Engenharia Nuclear
Sigla da Instituição: IEN
Tipo de Acesso: openAccess
Data do documento: Out-2015
Aparece nas coleções:Aplicação de técnicas nucleares na indústria, saúde e meio ambiente - Trabalhos de Congresso

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