Please use this identifier to cite or link to this item: http://carpedien.ien.gov.br:8080/handle/ien/861
Tipo: article
Título: 131I biokinetics and cytogenetic dose estimates in ablation treatment of thyroid carcinoma
Autor(es): NASCIMENTO, Ana Cristina
LIPSZTEIN, Joyce Landmann
CORBO, Rossana
REBELO, Ana Maria
Resumo: This study evaluated biokinetic behavior of radioiodine in the bodies of ten female adult patients, with well-differentiated thyroid cancer, treated with 131I post-near total thyroidectomy, for ablation of remnant thyroid. In vivo and in vitro bioassay analyses were performed from the first hour following radioiodine administration until minimum detection limits were reached. The retention of 131I in the body from day 1 to day 6 after the intake may be mathematically represented by an exponential decreasing curve, with an average biological half-life of approximately 0.81 d, with the exception of patients who presented thyroiditis. From day 6 to day 13, urinary excretion rates indicated an increased liberation of iodine. After 2 wk, the body retention of iodine followed an exponential decrease, with a half-life of about 15 d. The average whole-body dose for these patients was 0.27 Gy, as estimated through cytogenetic techniques.
Abstract: This study evaluated biokinetic behavior of radioiodine in the bodies of ten female adult patients, with well-differentiated thyroid cancer, treated with 131I post-near total thyroidectomy, for ablation of remnant thyroid. In vivo and in vitro bioassay analyses were performed from the first hour following radioiodine administration until minimum detection limits were reached. The retention of 131I in the body from day 1 to day 6 after the intake may be mathematically represented by an exponential decreasing curve, with an average biological half-life of approximately 0.81 d, with the exception of patients who presented thyroiditis. From day 6 to day 13, urinary excretion rates indicated an increased liberation of iodine. After 2 wk, the body retention of iodine followed an exponential decrease, with a half-life of about 15 d. The average whole-body dose for these patients was 0.27 Gy, as estimated through cytogenetic techniques.
Palavras-chave: radioiodine
in vitro bioassay
liberation of iodine
cytogenetic
CNPq: Instrumentação para Medida e Controle de Radiação. Produção de Radioisotopos.
Idioma: por
País: Brasil
Editor: Instituto de Engenharia Nuclear
Sigla da Instituição: IEN
Tipo de Acesso: restrictAccess
Identificador DOI: 10.1097/HP.0b013e3181c8f9ea.
URI: http://hdl.handle.net/ien/861
Data do documento: Oct-2010
Appears in Collections:Aplicação de técnicas nucleares na indústria, saúde e meio ambiente - Artigos de Periódicos

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